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Emerging Infection Sparks Urgency–Fungus is Unseen, Transmissible & Deadly

A newly emerged transmissible fungal infection, caused by Trichophyton mentagrophytes genotype VII (TMVII), has been identified in four adults in the US.

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Emerging Infection Sparks Urgency–Fungus is Unseen, Transmissible & Deadly | Credits: Getty Images

United States: A dermatophyte identified as Trichophyton mentagrophytes genotype VII (TMVII) has emerged as the culprit behind a nascent transmitted fungal infection, documented in four adults in the United States, as outlined in a recent issue of the Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report (MMWR).

TMVII, a transmissible fungal pathogen, is responsible for genital tinea and often poses as dermatological conditions such as eczema or psoriasis, mentioned Dr Jason E. Zucker, an infectious disease authority from Columbia University Irving Medical Center, alongside colleagues, according to medscape.com.

“Dermatophyte contagions like TMVII propagate predominantly via direct dermal contact,” remarked Dr. Avrom S. Caplan, a dermatology expert from NYU Grossman School of Medicine, in an interview.

“In the United States, we are only aware of occurrences among MSM [men who have sex with men]. However, cases have surfaced in Europe involving individuals outside the MSM demographic, including travelers engaged in sexual tourism in Southeast Asia or their infected partners,” Caplan noted.

Between April and July 2024, four individuals were diagnosed with tinea, with fungal cultures and DNA sequencing pinpointing TMVII as the pathogen. These men, aged 30-39 and residing in New York City, reported recent sexual encounters with other men; one engaged in sex work, two had sexual relations with one another, and one had recently traveled to Europe, as mentioned in medscape.com.

The patients presented with cutaneous eruptions localized to the face, buttocks, or genitalia. Antifungal therapy resolved symptoms in all cases.

Prompt Clinical Attention Advised 

Healthcare providers should maintain a high index of suspicion for TMVII in sexually active individuals with genital lesions, especially if concurrent pruritic, scaly, or inflamed eruptions appear elsewhere on the body, Caplan emphasized.

“Moreover, if a patient presents with ringworm on areas like the buttocks or face, particularly with a history of sexual activity, clinicians should inquire about genital lesions,” Caplan advised. He also stressed the importance of thorough evaluation for other sexually transmitted infections (STIs) in patients diagnosed with TMVII, particularly within the MSM population.

Call for Enhanced Surveillance 

Continued vigilance is imperative to comprehend the epidemiology of TMVII and emerging mycoses, Caplan stressed. Clinicians are encouraged to consult dermatophyte registries through platforms like the American Academy of Dermatology for updated information.

“We urgently require improved diagnostic access and more rapid confirmatory testing to detect emerging dermatophyte strains and monitor antifungal resistance,” Caplan added. Current data suggest no evidence of antifungal resistance in TMVII, distinguishing it from T. indotineae, he noted, according to medscape.com

Challenges in Diagnosis and Reporting 

“Emerging infections frequently mimic non-infectious ailments, complicating diagnoses,” commented Dr. Shirin A. Mazumder, an infectious disease scholar at The University of Tennessee Health Science Center. She underscored the significance of educating clinicians through case studies and encouraging the reporting of atypical presentations to public health authorities.

Skin conditions unresponsive to or exacerbated by corticosteroid use may serve as diagnostic indicators of TMVII, Mazumder explained. The fungus’s clinical manifestations, often mimicking eczema or psoriasis, necessitate thorough sexual history assessments, as transmission stems from intimate contact.

Future Research Directions 

Optimizing treatment protocols for TMVII remains an open question, Mazumder observed. The efficacy of combination regimens involving oral and topical antifungals versus monotherapy demands further exploration. Other knowledge gaps include determining transmissibility rates, periods of infectivity, reinfection risks, and the influence of host immunosuppression on disease trajectory, as per medscape.com.

Investigating long-term sequelae, bacterial coinfections, and the impact on broader patient populations will also yield critical insights, Mazumder concluded.

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Terror on US Soil—FBI Probes Bombing at Medical Center 

A deadly car bomb exploded outside a fertility clinic in Palm Springs, California, killing one and injuring four. The FBI has declared the blast an act of terrorism and launched a full-scale investigation. 

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United States: In a shocking incident that has rocked Palm Springs, California, the FBI has declared a recent car explosion an act of terrorism. 

Deadly Blast Rocks Palm Springs Clinic 

The blast occurred outside the American Reproductive Centers, a local fertility clinic, claiming one life and leaving four others injured. 

The explosion, which originated from a vehicle parked near the facility, tore through the area with devastating force. 

Emergency services quickly responded to the scene. Fortunately, no patients or clinic staff inside the building were harmed, although structural damage was reported. 

FBI Labels It Terrorism 

According to federal investigators, the FBI is leading the probe alongside local authorities and has already identified a person of interest connected to the case. Officials are now working to determine whether this act of violence was domestic or internationally inspired, though no official group or motive has yet been confirmed. 

This incident raises immediate concerns about the security of medical facilities and public areas across the US, especially amid rising tensions both at home and abroad. 

The FBI has assured the public that it is deploying all necessary resources to fully investigate the matter and ensure there are no further threats. 

Local law enforcement has increased patrols around critical infrastructure and public health facilities while urging citizens to report any suspicious activity. 

As the investigation continues, authorities emphasize the importance of community vigilance and staying informed through official updates. 

We will continue to follow this developing story closely and provide updates as more information becomes available. 

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Salman Rushdie’s Attacker Sentenced to 25 Years Behind Bars 

Hadi Matar, who stabbed novelist Salman Rushdie in 2022, has been sentenced to 25 years in prison, the maximum for attempted murder. Rushdie suffered severe injuries and is now partially blind from the attack. 

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United States: Hadi Matar, who attacked novelist Salman Rushdie last year, has been sentenced to 25 years in prison — the maximum for attempted murder. 

Matar received a conviction for second-degree attempted murder for the attack on Rushdie in 2022 while they were both at the Chautauqua Institution in New York. 

A man armed with a knife attacked Salman Rushdie as he was about to deliver a speech, inflicting injuries on the writer all over his body. 

Rushdie suffered severe damage to the eyes and nerves and is now partially blind because of the attack, npr.org reported. 

Rushdie wasn’t in the courtroom for Friday’s sentencing but wrote that he’s spent over 800 days in hospitals since the assault. 

Judge David Foley additionally ordered Matar to serve 7 years in prison on the charge of causing serious bodily injury to the event moderator. 

Rushdie’s novel The Satanic Verses created widespread outrage among many Muslims for its depiction of the Prophet Muhammad. 

Just before his passing in 1989, the Ayatollah Khomeini, the Supreme Leader of Iran, declared a legal judgment condemning Rushdie to death. 

Prosecutors from the Western District of New York argued that Matar was attempting to carry out the threat contained in the fatwa. 

Matar has affirmed that the fatwa didn’t inspire the attack but has explained to the New York Post that Rushdie had personally offended him by insulting Islam, npr.org reported. 

Matar told reporters that he had skimmed over just a few pages of The Satanic Verses. 

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150 Nations on Notice—Trump Sets Tariff Deadline Amid Slow Talks

Trump warned that countries delaying trade deals will soon face steep tariffs, with letters outlining new rates expected in 2–3 weeks. 

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United States: After completing his trip to the Middle East, Trump admitted that the negotiation pace was insufficient to finalize agreements with all countries interested in a trade deal. 

Trump stated that countries have a limited amount of time to reach agreements with American authorities, after which Secretary Scott Bessent and Secretary Howard Lutnick will inform other nations of the new tariffs they must impose. 

According to Trump, while speaking at a business roundtable in Abu Dhabi on Friday, “We have, at the same time, 150 countries that want to make a deal, but you’re not able to see that many countries,” CNN reported. 

“So at a certain point, over the next two to three weeks, I think Scott and Howard will be sending letters out, essentially telling people – we’ll be very fair – but we’ll be telling people what they’ll be paying to do business in the United States,” he added. 

Trump had announced on April 2 “Liberation Day,” and on April 9, he temporarily halted the imposition of reciprocal tariffs on many countries. 

The pause was to last for 90 days while countries work with the American government to craft new agreements. 

The administration now faces enormous pressure to speed up the negotiations to finalize new deals since some 100 countries have reportedly expressed interest in this. 

The president could slap reciprocal tariffs that could be as much as 50% without those accords in place. 

Since the proposed tariffs don’t apply in equal measures to all countries, and many nations import far more from the United States than they import from it, many governments would be adversely affected. 

President Trump had previously announced something similar, but the deadline set since then has already passed. 

During the previous month, Trump indicated that countries refusing to make new deals within a few weeks’ time frame would face tariff increases. 

“I guess you could say they could appeal it, but for the most part, I think we’re going to be very fair, but it’s not possible to meet the number of people that want to see us,” Trump added. 

On April 23, in the Oval Office, Trump stated that his administration would “set the tariff” for countries that fail to negotiate new terms in the following few weeks. 

“In the end, I think what’s going to happen is we’re going to have great deals, and by the way, if we don’t have a deal with a company or a country, we’re going to set the tariff,” as Trump stated last month. 

“I’d say over the next couple of weeks, wouldn’t you say? I think so, over the next two or three weeks. We’ll be setting the number,” Trump mentioned. 

Thus far, the US government has unveiled two new arrangements for international trade talks, leading to less tariff protection or reduced trade restrictions with other economies. 

The first of these outcomes included the United Kingdom agreeing to lower tariffs on items imported into the United States last month, while the second was the recent agreement with China on a Beijing-led global initiative to increase openness to foreign companies. 

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