News
Flu + Antibiotics = A Recipe for Disaster? Combination Might Be Making Your Flu Worse

United States: A groundbreaking study has shed light on the detrimental repercussions of antibiotic use during influenza infections, particularly its role in amplifying lung eosinophil levels and compromising the immune system’s capacity to fend off secondary bacterial invaders. This investigation underscores the necessity of reevaluating antibiotic deployment in the context of viral illnesses.
Methodological Framework
Employing a murine model, researchers meticulously examined the ramifications of administering a broad-spectrum antibiotic regimen—including vancomycin, neomycin, ampicillin, and metronidazole—commencing seven days prior to influenza infection, as per medscape.com.
Key investigative steps included:
1. Intranasal Viral Introduction: Mice were subjected to controlled influenza infection, succeeded by exposure to methicillin-resistant Staphylococcus aureus (MRSA) as a secondary bacterial challenge.
2. Immune Profiling: Lung eosinophil levels, macrophage functionality, and bacterial clearance were quantified using a suite of immunological and histological techniques.
3. Human Cohort Analysis: Hospitalized patient groups were analyzed to determine correlations between eosinophil concentrations, antibiotic administration, systemic inflammation, and clinical outcomes.
Key Discoveries
The findings revealed profound immune dysregulation:
– Pulmonary Eosinophilia and Macrophage Dysfunction: Antibiotic intervention disrupted the gut mycobiome, triggering fungal dysbiosis. This imbalance catalyzed an upsurge in lung eosinophils, which, via major basic protein 1 (MBP-1) release, inhibited alveolar macrophages’ bactericidal capacity.
– Impaired Bacterial Clearance: The murine model demonstrated reduced efficiency in eliminating MRSA, which is directly linked to antibiotic-induced immune alterations.
– Human Parallels: Analysis of hospitalized cohorts affirmed that elevated eosinophil levels were strongly associated with antibiotic use, heightened systemic inflammation, and poorer clinical outcomes.
Practical Implications
“Our research elucidates the insidious effects of antibiotics during viral infections, illustrating a mechanism by which gut fungal imbalances incite lung eosinophilia. This cascade ultimately impairs bacterial clearance by alveolar macrophages, a critical component of lung immunity,” stated the study’s authors, according to medscape.com.
Acknowledging Study Constraints
While the study delivers compelling insights, several limitations warrant consideration:
1. Murine Model Caveats: Animal studies do not always perfectly mirror human immunological dynamics.
2. Antibiotic Specificity: Results were confined to the specific cocktail utilized, potentially differing with other antibiotic combinations.
3. Infection Model Scope: Findings pertain exclusively to the dual-hit scenario of influenza followed by MRSA, potentially limiting applicability to other infection sequences.
Study Provenance and Financial Support
This pivotal research was spearheaded by Marilia Sanches Santos Rizzo Zuttion at Cedars-Sinai Medical Center, Los Angeles, and published in The Journal of Clinical Investigation. Funding support was provided by the National Institutes of Health, with additional research sponsorship from Pfizer Inc. Comprehensive disclosures are available in the primary publication, as per medscape.com.
This study emphasized the critical need for judicious antibiotic use, particularly during viral infections, to avoid unintended immune suppression and exacerbation of secondary bacterial risks. The findings highlight an intricate interplay between gut and lung immunity that demands further exploration.
News
‘Take It Down Act’ Targets Online Abuse, Backed by First Lady
New law demands quick removal of non-consensual explicit content online. Melania Trump leads charge to protect teens from digital abuse and AI deepfakes.

United States: On Monday, the president and first lady gathered in the White House Rose Garden so he could sign a new law addressing revenge porn which was championed by the first lady.
“I want to thank my husband, President Trump, for standing with us on this effort,” Melania Trump stated, with a riot of pink roses in bloom behind her.
What is the Take It Down Act?
The bill, known as the Take It Down Act, commands social media platforms to promptly take down sexually explicit pictures and videos of others, including “deepfakes,” if they were uploaded without consent. It was created to support teen survivors.
Melania Trump’s Mission to Protect Teens
“Artificial Intelligence and social media are the digital candy for the next generation — sweet, addictive and engineered to have an impact on the cognitive development of our children,” the first lady stated, the New York Times reported.
“But unlike sugar, these new technologies can be weaponized, shape beliefs and, sadly, affect emotions and even be deadly,” she added.
This guide focuses on teenage victims of FGM. Mrs. Trump was determined to get the bill passed from the day of her husband’s second inauguration, the day Senator Amy Klobuchar, Democrat of Minnesota, first mentioned it over lunch.
Like Be Best, Mrs. Trump’s anti-cyberbullying effort from the previous four years, the bill was a great fit for the first couple’s focus on battling digital meanness.
Early in March, she visited Washington to lead a roundtable with girls who had fallen victim to online attacks and the father of a young boy who left the world because of internet “sextortion.”
The event was emotional at times, and after it was over, Mrs. Trump took some of the guests to see the president address Congress the next day, where he discussed the bill, the New York Times reported.
News
Terror on US Soil—FBI Probes Bombing at Medical Center
A deadly car bomb exploded outside a fertility clinic in Palm Springs, California, killing one and injuring four. The FBI has declared the blast an act of terrorism and launched a full-scale investigation.

United States: In a shocking incident that has rocked Palm Springs, California, the FBI has declared a recent car explosion an act of terrorism.
Deadly Blast Rocks Palm Springs Clinic
The blast occurred outside the American Reproductive Centers, a local fertility clinic, claiming one life and leaving four others injured.
The explosion, which originated from a vehicle parked near the facility, tore through the area with devastating force.
Emergency services quickly responded to the scene. Fortunately, no patients or clinic staff inside the building were harmed, although structural damage was reported.
🚨 NEW: Preliminary OSINT Brief – Palm Springs Fertility Clinic Bombing (May 17, 2025)
— Prime Rogue Inc (@PrimeRogueInc) May 17, 2025
This morning’s explosion at American Reproductive Centers marks the first major anti-IVF terror attack in U.S. history
Here’s what we know—and what we’re watching. 🧵
🔗 https://t.co/GZeSw0S4Gr
FBI Labels It Terrorism
According to federal investigators, the FBI is leading the probe alongside local authorities and has already identified a person of interest connected to the case. Officials are now working to determine whether this act of violence was domestic or internationally inspired, though no official group or motive has yet been confirmed.
This incident raises immediate concerns about the security of medical facilities and public areas across the US, especially amid rising tensions both at home and abroad.
The FBI has assured the public that it is deploying all necessary resources to fully investigate the matter and ensure there are no further threats.
Local law enforcement has increased patrols around critical infrastructure and public health facilities while urging citizens to report any suspicious activity.
As the investigation continues, authorities emphasize the importance of community vigilance and staying informed through official updates.
We will continue to follow this developing story closely and provide updates as more information becomes available.
News
Salman Rushdie’s Attacker Sentenced to 25 Years Behind Bars
Hadi Matar, who stabbed novelist Salman Rushdie in 2022, has been sentenced to 25 years in prison, the maximum for attempted murder. Rushdie suffered severe injuries and is now partially blind from the attack.

United States: Hadi Matar, who attacked novelist Salman Rushdie last year, has been sentenced to 25 years in prison — the maximum for attempted murder.
Matar received a conviction for second-degree attempted murder for the attack on Rushdie in 2022 while they were both at the Chautauqua Institution in New York.
A man armed with a knife attacked Salman Rushdie as he was about to deliver a speech, inflicting injuries on the writer all over his body.
Rushdie suffered severe damage to the eyes and nerves and is now partially blind because of the attack, npr.org reported.
Rushdie wasn’t in the courtroom for Friday’s sentencing but wrote that he’s spent over 800 days in hospitals since the assault.
Judge David Foley additionally ordered Matar to serve 7 years in prison on the charge of causing serious bodily injury to the event moderator.
Rushdie’s novel The Satanic Verses created widespread outrage among many Muslims for its depiction of the Prophet Muhammad.
Just before his passing in 1989, the Ayatollah Khomeini, the Supreme Leader of Iran, declared a legal judgment condemning Rushdie to death.
Prosecutors from the Western District of New York argued that Matar was attempting to carry out the threat contained in the fatwa.
Matar has affirmed that the fatwa didn’t inspire the attack but has explained to the New York Post that Rushdie had personally offended him by insulting Islam, npr.org reported.
Matar told reporters that he had skimmed over just a few pages of The Satanic Verses.
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